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UDC 577.12 BBK E 902 K21 Karasev VA. Principles of topological
coding of chain polymers and protein structure / SPbGETU
«LETI». SPb, 2014. 240 pp. A theory of topological coding of linear chain
polymers is proposed, which includes a topological code and a system of
physical operators. The elementary unit of the code is the polymer pentafragment, the conformation of which is described by
a four-arc graph, and the physical operators are the side chains of the
polymer, which recreate the encoded structure of the pentafragments. The idea of a molecular vector
machine is introduced, according to which the vectors acting on the formation
of the hydrogen bond in the pentafragment form a
group, and the side chains of the polymer act as irreducible representations
of the group of vectors realizing the action of the latter in the process of
reconstructing the topology of the chain polymer. The application of this
theory to proteins and nucleic acids makes it possible to explain the nature
of the genetic code, the structure of the canonical set of amino acids, and
the problem of the "triplet-amino acid" correspondence in the
genetic code. On the basis of the concepts introduced, a
database of protein pentapragments and a library of
ten-digit descriptions of the secondary structure of proteins have been
created, and simple and effective methods for predicting and designing the
secondary structure of proteins have been proposed. The theory outlines the use of chain polymers to
create fundamentally new devices for nanoelectronics.
The book is intended for specialists working in molecular biology and nanoelectronics, as well as for students and
post-graduate students specializing in these fields of science and
technology. |
The scientific edition